CARA 3.2 EC

Insecticides and acaricides

CARA 3.2 EC

Insecticides & Acaricides IRAC GROUP 6 Main Group and Primary Site of Action : Glutamate-gated chloride channel (GluCl)allosteric modulators Nerve and muscle action Strong evidence that action at one or more of this class of protein is responsible forinsecticidal effects

Chemical Class Avermectins-Milbemycins (6)

Avermectins are 16-membered macrocyclic lactones produced by Streptomyces avermitilis, and abamectin is a blend of avermectinB1a and avermectin B1b. The anthelminthic,insecticidal, and acaricidal activities of avermectins are well known and their mode ofaction is via blocking-amino butyric acid-stimulated chloride channels and open non- neurotransmitter-gated chloride channels. This causes an ionimbalance in the nervous system, resulting in paralysis.

Abamectin is a widely used insecticide and anthelmintic. Abamectin,is a member of the Avermectin family and is a naturalfermentation product of soil dwelling actinomycete Streptomyces avermitilis.

Avermectins bind to the glutamate-gated chloride channels that are found in invertebrate nerve and muscle cells. They causehyperpolarization of these cells resulting in paralysis and death. Mammals only possess glutamate-gated chloride channels in thebrain and spinal cord and as the Avermectins have a low affinity for other mammalian ligand-gated channels and do not usually crossthe blood–brain barrier, they are very safe for mammals